TABLE 3.
Functional antibodies generated by the V3-L2-V5 fusion vaccine candidate as determined in serum bactericidal assaysa
| Immune serum | SB titerb
: |
|||||
|---|---|---|---|---|---|---|
| ST1 | ST2 | ST3 | ST4 | ST5 | ST6 | |
| FL-OspA | 160 | 500 | 2,500 | 160 | 12,500 | 20 |
| V3-L2-V5 | 160 | 500 | <20 | 40 | 500 | 2,500 |
a
Growth inhibition assay was analyzed with B. burgdorferi ZS7 (ST1), B. afzelii LU171 (ST2), B. garinii PFr (ST3), B. bavariensis DK6 (ST4), B. garinii PHei (ST5), and KL11 (ST6) strains.
b
Serum bactericidal (SB) titer is defined as the reciprocal of the lowest dilution with ≥50% reduction in spirochetes compared to negative sera.