FIG 3.

Pretreatment of mice with M. muris improves clinical outcomes and reduces otitis media-induced weight loss in the NTHi otitis media model. Mean clinical score (A) and weight loss (B) for mice with (closed black circles; n = 12 by day 7) or without (white circles; n = 15 by day 7) M. muris (Mm) pretreatment. Values are presented as the mean ± standard error of the mean. D, days postchallenge with influenza A virus challenge (IAV) as the reference point. NTHi was administered on day 3 and mice monitored to day 7; *, P < 0.01 when compared between treatment groups.