Table 3. Allele and genotype distributions of CTNNAL1 among HSCR patients and normal controls.
| SNP ID | Genotype frequency (%) | H-W check p value* | P value* | FDR adjusted | Allele frequency (%) | X2 | P value* | FDR adjusted | Odds Ratio (95%CI) | |||
| rs10816766 | CC | CT | TT | C | T | |||||||
| Case | 32(6.4) | 164(32.7) | 305(60.9) | 0.123 | 0.249 | > 0.05 | 228(22.8) | 774 (77.2) | 0.484 | 0.487 | > 0.05 | 1.08(0.87-1.33) |
| Control | 21(4.1) | 177(34.7) | 312(61.2) | 0.510 | 219(21.5) | 801(78.5) | ||||||
| rs10979650 | AA | AG | GG | A | G | |||||||
| Case | 23(4.6) | 146(29.3) | 330(66.1) | 0.192 | 0.017 | > 0.05 | 192(19.2) | 806(80.8) | 7.241 | 0.007 | 0.039 | 1.38(1.09-1.74) |
| Control | 10(2.0) | 131(25.6) | 371(72.5) | 0.690 | 151(14.7) | 873(85.3) | ||||||
| rs4978766 | AA | AG | GG | A | G | |||||||
| Case | 333(66.3) | 147(29.3) | 22(4.4) | 0.267 | 0.025 | > 0.05 | 813(81.0) | 191(19.0) | 6.617 | 0.010 | 0.028 | 0.73(0.58-0.93) |
| Control | 371(72.5) | 131(25.6) | 10(2.0) | 0.690 | 873(85.3) | 151(14.7) | ||||||
| rs4978379 | CC | CG | GG | C | G | |||||||
| Case | 327(65.5) | 146(29.3) | 26(5.2) | 0.073 | 0.005 | > 0.05 | 800(80.2) | 198(19.8) | 9.437 | 0.002 | 0.023 | 0.70(0.55-0.88) |
| Control | 371(72.6) | 130(25.4) | 10(2.0) | 0.722 | 872(85.3) | 150(14.7) | ||||||
| rs2282206 | AA | AG | GG | A | G | |||||||
| Case | 144(28.8) | 248(49.6) | 108(21.6) | 0.950 | 0.768 | > 0.05 | 536(53.6) | 464(46.4) | 0.104 | 0.748 | > 0.05 | 0.97(0.82-1.16) |
| Control | 156(30.6) | 242(47.5) | 112(22.0) | 0.322 | 554(54.3) | 466(45.7) | ||||||
| rs838816 | CC | CT | TT | C | T | |||||||
| Case | 113(22.6) | 251(50.2) | 136(27.2) | 0.891 | 0.600 | > 0.05 | 477(47.7) | 523(52.3) | 0.140 | 0.708 | > 0.05 | 1.03(0.87-1.23) |
| Control | 119(23.3) | 241(47.2) | 151(29.5) | 0.231 | 479(46.9) | 543(53.1) | ||||||
| rs838817 | CC | CT | TT | C | T | |||||||
| Case | 141(28.1) | 249(49.7) | 111(22.2) | 0.957 | 0.614 | > 0.05 | 531(53.0) | 471(47.0) | 0.250 | 0.617 | > 0.05 | 0.96(0.80-1.14) |
| Control | 157(30.7) | 240(46.9) | 115(22.5) | 0.204 | 554(54.1) | 470(45.9) | ||||||
| rs7021366 | CC | CG | GG | C | G | |||||||
| Case | 195(39.0) | 235(47.0) | 70(14.0) | 0.952 | 0.020 | > 0.05 | 625(62.5) | 375(37.5) | 7.169 | 0.007 | 0.027 | 0.78(0.65-0.95) |
| Control | 244(47.7) | 210(41.0) | 58(11.3) | 0.214 | 698(68.2) | 326(31.8) | ||||||
| rs7027874 | AA | AG | GG | A | G | |||||||
| Case | 143(28.7) | 243(48.8) | 112(22.5) | 0.651 | 0.784 | > 0.05 | 529(53.1) | 467(46.9) | 0.443 | 0.505 | > 0.05 | 0.94(0.79-1.12) |
| Control | 157(30.7) | 245(047.9) | 110(21.5) | 0.431 | 559(54.6) | 465(45.4) | ||||||
| rs2289481 | CC | CG | GG | C | G | |||||||
| Case | 111(22.2) | 246(49.3) | 142(28.5) | 0.820 | 0.711 | > 0.05 | 468(46.9) | 530(53.1) | 0.386 | 0.534 | > 0.05 | 1.06(0.89-1.26) |
| Control | 112(21.8) | 243(47.4) | 158(30.8) | 0.309 | 467(45.5) | 559(54.5) | ||||||
| rs2289480 | AA | AC | CC | A | C | |||||||
| Case | 141(28.3) | 246(49.3) | 112(22.4) | 0.811 | 0.673 | > 0.05 | 528(52.9) | 470(47.1) | 0.506 | 0.477 | > 0.05 | 0.94(0.79-1.12) |
| Control | 158(30.8) | 243(47.4) | 112(21.8) | 0.309 | 559(54.5) | 467(45.5) | ||||||
*Pearson's p value, FDR = false discovery rate, SNP = single nucleotide polymorphism, CI = confidence interval, HSCR = Hirschsprung disease.