Table 2. Associations between telomere length and cognitive function in the AD cognitive stage groups.

	MMSE			CERAD			CDR-SB			LM delayed recall
	b* (95% CI)	P†		b* (95% CI)	P†		b* (95% CI)	P†		b* (95% CI)	P†
CU A- (N = 104)
TL	0.190 (-0.042 ~ 0.422)	0.108		-0.446 (-1.314 ~ 0.421)	0.310		-0.001 (-0.006 ~ 0.004)	0.706		-0.476 (-1.160 ~ 0.208)	0.170
CU A+ (N = 26)
TL	0.339 (-0.037 ~ 0.715)	0.075		-0.480 (-2.151 ~ 1.192)	0.557		0.002 (-0.016 ~ 0.020)	0.811		-0.268 (-1.218 ~ 0.681)	0.562
MCI A+ (N = 28)
TL	1.026 (0.047 ~ 2.005)	0.041		2.487 (-0.090 ~ 5.060)	0.058		-0.128 (-0.348 ~ 0.092)	0.242		1.048 (0.348 ~ 1.747)	0.005
ADD A+ (N = 35)
TL	0.356 (-0.351 ~ 1.063)	0.312		1.539 (-0.287 ~ 3.365)	0.095		-0.040 (-0.499 ~ 0.420)	0.862		0.072 (-0.162 ~ 0.306)	0.535
All A+ (N = 89)
TL	0.531 (0.070 ~ 0.991)	0.024		1.244 (-0.348 ~ 2.836)	0.124		-0.058 (-0.300 ~ 0.184)	0.636		0.334 (-0.139 ~ 0.808)	0.164

TL, telomere length; CU, cognitively unimpaired; MCI, mild cognitive impairment; ADD, Alzheimer’s disease dementia; A−, absence of amyloid pathology determined by normal amyloid PET finding or CSF study; A+, presence of amyloid pathology determined by abnormal amyloid PET finding or CSF study; MMSE, Mini-Mental State Examination; CERAD, Consortium to Establish a Registry for AD; CDR-SB, Clinical Dementia Rating-Sum of Boxes; LM, logical memory; CI, confidence interval. ^*Unstandardized coefficient of regression. ^†Linear regression analysis with each cognitive function test as dependent variable and TL as independent variable, controlling for age, sex, and education.