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. 2020 Mar 12;12(5):4067–4081. doi: 10.18632/aging.102636

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Copyright © 2020 Zhang et al.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY 3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

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The pathological changes of hippocampal neurons in the MPTP-lesioned mouse model of PD. (A) The ultrastructure of hippocampal neurons treated with si-Hif1a or oe-Hif1a to electron microscopy. (B) The pathological changes of hippocampal neurons treated with si-Hif1a or oe-Hif1a revealed by HE staining (scale bar = 50 μm). (C) The apoptosis of hippocampal neurons treated with si-Hif1a or oe-Hif1a detected by TUNEL staining (scale bar = 50 μm). * p < 0.05 vs. the NC group (MPTP-lesioned mice treated with NC plasmids). N = 10.