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. 2020 Mar 12;12(5):4558–4572. doi: 10.18632/aging.102911

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Copyright © 2020 Wang et al.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY 3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

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RHPN1-AS1 is overexpressed in EOC tissues and cells and predicts poor prognosis. (A) The heat map of lncRNAs with the largest difference between the three pairs of EOC and control tissues (P < 0.05). (B, C) RHPN1-AS1 expression in EOC specimens, control tissues, and EOC cell lines. (D–F) Association between RHPN1-AS1 expression and survival by Kaplan–Meier analysis. (G) m6A methylation level of RHPN1-AS1 in EOC cells and HOSEPIC cells determined by MeRIP-qPCR. (H) Changes in m6A-modified RHPN1-AS1 levels after METTL3 sectioning in HEY cells. (I) METTL3 and RHPN1-AS1 expressions in sh-METTL3-HEY cells. (J) RHPN1-AS1 stability was decreased in HEY cells with METTL3 knockdown. (K) Correlation between RHPN1-AS1 and METTL3 expression in EOC tissues.*P<0.05, **P<0.01.