Extended Data Table 1. Subunit composition of RSC and related chromatin remodelling complexes.

Assignment to the structural modules based on the S. cerevisiae structure of RSC presented in this work. Subunits occurring together in the complex are separated by comma, a slash indicates the use of one of the subunits. Subunits that could not be assigned to a module by homology are listed below. The PBAF subunit BAF200⁸³ likely corresponds to Rsc9 because it comprises an armadillo repeat fold⁵³, and the BAF180 subunit comprises regions that resemble Rsc2 and Rsc4⁸⁴. Only the small RSC subunits Rsc58, Rtt102 and Htl1 lack obvious counterparts. PBAF subunits contain 12 DNA-binding domains located in subunits BAF180 (HMG box)⁸⁵, BAF200 (AT-rich domain, two C2H2 zinc fingers, RFX domain)⁸³, BAF57 (HMG box)⁸⁶ and BCL11A/B (six C2H2 zinc fingers)⁸⁷. The BAF subunit BAF250a is predicted to contain five armadillo repeats⁸⁸, and is likely the counterpart of Rsc9.

Module	S. cerevisiae		S. pombe		D. melanogaster		H.sapiens
	RSC	SWI/SNF	RSC	SWI/SNF	PBAP	BAP	PBAF	BAF
ATPase module	Sth1	Snf2	Snf21	Snf22	BRM	BRM	BRG1	BRG1/BRM
Arp module	Arp9	Arp9	Arp9	Arp9	β-actin	β-actin	β-actin	β-actin
	Arp7	Arp7	Arp42	Arp42	BAP55	BAP55	BAF53A/B	BAF53A/B
	Rtt102	Rtt102
arm module	Sfh1	Snf5	Sfh1	Snf2	SNR1	SNR1	BAF47	BAF47
	Npl6	Swp82	Rsc7	Snf59
body module	Rsc6	Swp73	Ssr3	Ssr3	BAP60	BAP60	BAF60A/B/C	BAF60A/B/C
	Rsc9	Swi1	Rsc9	Soli	BAP 170	OSA	BAF200	BAF250A/B
	Htl1
	Rsc58		Rsc58
	Rsc4		Rsc4		Polybromo		BAF 180
	Rsc2 / Rsc1		Rsc1
DNA-interaction module	Rsc3
	Rsc30
Scaffold	Rsc8, Rsc8	Swi3, Swi3	Ssr1, Ssr2	Ssrl, Ssr2	MOR, MOR	MOR, MOR	BAF 155, BAF 170	BAF 155, BAF 170
	Ldb7
					BAP111	BAP111	BAF57	BAF57
		Snf11
		Snf6
		Taf14		Tfg3
				Snf30
					SAYP		BAF45A	BAF45A/B/C
							BRD7	BRD9
							BCL11A/B	BCL11A/B
							BCL7A/B/C	BCL7A/B/C
							SS18/SS18L1