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. Author manuscript; available in PMC: 2021 Mar 19.
Published in final edited form as: Cell Chem Biol. 2020 Jan 7;27(3):269–282.e5. doi: 10.1016/j.chembiol.2019.12.008

Figure 5: Structure activity relationships and metabolic stability of GW and analogs.

Figure 5:

A, Antifungal activity in relationship to alterations to the core heterocycles of GW. Compounds that showed >80% fungal inhibition at a concentration less than 50 μM are indicated in red as active. B, Metabolic stability in relationship to heterocycle alterations. Compounds were incubated with mouse liver microsomes in the presence of NADPH and fraction of parent material remaining quantified at various time points over an hour to determine half-life (T1/2) and intrinsic clearance (Clint). C, Antifungal activity in relationship to changes to the hinge-binding moieties of GW. Activity defined as in panel A.