Table 3.
Cross-sectional associations between DGIH/BMI and depressive episode (age 18 years)
| Predictor | Odds ratio (95% CI) for depressive episode | |||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Adjustments | ||||||||||||
| Depressive episode | Unadjusted model | Demographic adjustments (sex, birth social class, ethnicity, maternal education, maternal EPDS score) |
Lifestyle adjustments (BMIa, HOMA2b, smoking, alcohol use, physical activity) |
Immune adjustments [IL-6 (9 years), CRP (18 years)] |
Complete model (all adjustments) |
|||||||
| N outcome | n | OR (95% CI) | p | OR (95% CI) | p | OR (95% CI) | p | OR (95% CI) | p | OR (95% CI) | p | |
| HOMA2 | 227 | 3208 | 1.14 (1.01–1.31) | 0.047* | 1.07 (0.97–1.24) | 0.296 | 1.12 (0.97–1.30) | 0.132 | 1.15 (1.01–1.32) | 0.042* | 1.05 (0.91–1.23) | 0.498 |
| FPG | 227 | 3208 | 0.90 (0.77–1.05) | 0.174 | 1.02 (0.88–1.18) | 0.787 | 0.89 (0.76–1.03) | 0.115 | 0.89 (0.77–1.05) | 0.165 | 1.00 (0.87–1.17) | 0.959 |
| FI | 227 | 3208 | 1.16 (1.01–1.33) | 0.034* | 1.09 (0.94–1.25) | 0.269 | 1.13 (0.98–1.32) | 0.098 | 1.16 (1.02–1.34) | 0.029* | 1.06 (0.91–1.24) | 0.794 |
| BMI | 227 | 3208 | 1.02 (0.99–1.06) | 0.138 | 1.02 (0.98–1.05) | 0.305 | 1.01 (0.98–1.05) | 0.486 | 1.03 (0.99–1.07) | 0.107 | 1.02 (0.98–1.06) | 0.368 |
a
Not adjusted for in BMI analysis.
b
Not adjusted for in HOMA/FPG/FI analysis.
*Indicates p < 0.05.