Table 5.
Longitudinal association between DGIH/BMI (age 9) and depressive episode (age 18 years)
| Predictor | Odds ratio (95% CI) for depressive episode (age 18 years) | |||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Adjustments | ||||||||||||
| Depressive episode (18 years) | n outcome | Unadjusted model | Demographic adjustments (sex, birth social class, ethnicity, maternal education, maternal EPDS score) |
Lifestyle adjustments (BMIa, HOMA2b, physical activity) |
Immune adjustments [IL-6 (9 years)] |
Complete model (all adjustments) |
||||||
| n | OR (95% CI) | p | OR (95% CI) | p | OR (95% CI) | p | OR (95% CI) | p | OR (95% CI) | p | ||
| 2hrGT (age 9 years) | 23 | 313 | 1.21 (0.95–1.54) | 0.235 | 0.98 (0.73–1.31) | 0.891 | 0.91 (0.60–1.38) | 0.641 | 0.91 (0.60–1.39) | 0.651 | 0.85 (0.55–1.30) | 0.427 |
| HOMA2 (age 9 years) | 23 | 313 | 1.16 (0.86–1.20) | 0.387 | 1.14 (0.75–1.72) | 0.538 | 0.98 (0.74–1.31) | 0.896 | 0.98 (0.74–1.30) | 0.893 | 0.98 (0.83–1.31) | 0.977 |
| FPG (age 9 years) | 23 | 313 | 1.03 (0.90–1.07) | 0.446 | 0.85 (0.55–1.30) | 0.442 | 1.08 (0.73–1.61) | 0.693 | 1.05 (0.69–1.58) | 0.830 | 1.19 (0.78–1.84) | 0.678 |
| FI (age 9 years) | 23 | 313 | 1.10 (0.90–1.21) | 0.250 | 1.01 (0.75–1.34) | 0.971 | 1.01 (0.75–1.33) | 0.995 | 1.02 (0.77–1.34) | 0.916 | 0.97 (0.74–1.33) | 0.916 |
| BMI (age 9 years) | 170 | 2571 | 1.23 (0.76–1.32) | 0.687 | 1.04 (0.98–1.10) | 0.127 | 1.05 (0.98–1.11) | 0.058 | 1.06 (0.97–1.12) | 0.060 | 1.05 (0.98–1.12) | 0.070 |
a
Not adjusted for in BMI analysis.
b
Not adjusted for in HOMA/FPG/FI analysis.
*Indicates p < 0.05.