Table 1.
Descriptive characteristics of study population
| Characteristic | PCOS-exposed offspring (N = 20 988) | PCOS-unexposed offspring (unrelated) (N = 200 816) | PCOS-unexposed offspring (cousins) (N = 17 295) | |||
|---|---|---|---|---|---|---|
| n | % | n | % | n | % | |
| Sex of offspring | ||||||
| Male | 10 779 | 51.36 | 102 528 | 51.06 | 8940 | 51.69 |
| Female | 10 209 | 48.64 | 98 288 | 48.94 | 8355 | 48.31 |
| Child's year of birth | ||||||
| 1973–1984 | 314 | 1.5 | 3317 | 1.65 | 817 | 4.72 |
| 1985–1989 | 539 | 2.57 | 6869 | 3.42 | 1151 | 6.66 |
| 1990–1994 | 1333 | 6.35 | 16 739 | 8.34 | 2059 | 11.91 |
| 1995–1999 | 2034 | 9.69 | 23 402 | 11.65 | 2213 | 12.8 |
| 2000–2004 | 3398 | 16.19 | 38 105 | 18.98 | 3242 | 18.75 |
| 2005–2009 | 6397 | 30.48 | 57 488 | 28.63 | 4284 | 24.77 |
| 2010–2013 | 6973 | 33.22 | 54 896 | 27.34 | 3529 | 20.4 |
| Maternal age at child's birth (years) | ||||||
| <20 | 540 | 2.57 | 6296 | 3.14 | 722 | 4.17 |
| 20–24 | 3847 | 18.33 | 43 570 | 21.70 | 4158 | 24.04 |
| 25–29 | 7108 | 33.87 | 74 121 | 36.91 | 6086 | 35.19 |
| 30–34 | 6486 | 30.90 | 57 995 | 28.88 | 4637 | 26.81 |
| 35+ | 3007 | 14.33 | 18 834 | 9.38 | 1692 | 9.78 |
| Mother's region of birth | ||||||
| The Nordic countries | 16 595 | 79.07 | 167 284 | 83.30 | 15 432 | 89.23 |
| Outside the Nordic countries | 4393 | 20.93 | 33 532 | 16.70 | 1863 | 10.77 |
| Maternal highest achieved educationa | ||||||
| Primary and secondary education | 2152 | 10.3 | 19 650 | 9.85 | 2019 | 11.72 |
| Upper secondary education | 9087 | 43.47 | 88 465 | 44.33 | 8267 | 47.98 |
| Post-secondary/post-graduate education | 9664 | 46.23 | 91 424 | 45.82 | 6945 | 40.31 |
| Maternal lifetime history of any psychiatric diagnosis | 4660 | 22.2 | 31 294 | 15.58 | 2914 | 16.85 |
| Paternal lifetime history of any psychiatric diagnosis | 2318 | 11.04 | 20 898 | 10.41 | 1845 | 10.67 |
| Offspring psychiatric disorders | ||||||
| ADHD | 681 | 3.24 | 5440 | 2.71 | 602 | 3.48 |
| ASD | 256 | 1.22 | 1765 | 0.88 | 202 | 1.17 |
| TD/CTD | 38 | 0.18 | 282 | 0.14 | 30 | 0.17 |
ADHD, attention-deficit/hyperactivity disorder; ASD, autism spectrum disorders; PCOS, polycystic ovary syndrome; TC/CTD, Tourette disorder/chronic tic disorder.
Categories do not add up to the total number because maternal education is missing for 0.6% of children.