Table 1.

Representative ROS-scavenging inorganic nanoparticles.

Nanoparticles	Applications	Evaluation models	Administration routes	References
Fullerenes	Cortical infarction	In vivo in rats	Intravenous or intracerebroventricular injection	Lin et al., 2002
	Amyotrophic lateral sclerosis	In vivo in mice	Loaded into mini-osmotic pumps and implanted into the peritoneum	Dugan et al., 1997
	Alzheimer's disease	In vivo in rats	Intrahippocampal injection	Gordon et al., 2017
	Asthma	In vitro in human lung mast cells; in vivo in mice	Intranasal administration	Norton et al., 2012
Ceria oxide nanoparticles	Liver fibrosis	In vivo in rats	Intravenous injection	Oró et al., 2016
	Photoreceptor degeneration	In vivo in mice/rats	Intracardial injection; Intravitreal injection	Kong et al., 2011; Cai et al., 2012; Wong et al., 2013, 2015
	Alzheimer's disease	In vivo in mice	Unilateral subicular injection	Kwon et al., 2016
	Multiple sclerosis	In vivo in mice	Intravenous injection	Heckman et al., 2013
Platinum nanoparticles	Cerebral cavernous malformation disease	In vitro in HeLa, MCF-7, and Caco-2 cells	N/A	Moglianetti et al., 2016
	Cerebral ischemia	In vivo in mice	Intravenous injection	Takamiya et al., 2012
Manganese-based nanoparticles	Parkinson's Disease	In vitro in SH-SY5Y cells	N/A	Singh et al., 2017
	Ear-inflammation	In vitro in HeLa cells; in vivo in mice	Subcutaneous injection	Yao et al., 2018
Prussian blue nanoparticles	Liver inflammation	In vitro in HUVECs, RAW264.7, HBZY-1, NIH-3T3, and HT cells; in vivo in mice	Intravenous injection	Zhang W. et al., 2016
Molybdenum nanoparticles	Acute kidney injury	In vitro in HEK293 cells; in vivo in mice	Intravenous injection	Ni et al., 2018
V2O5@pDA@ MnO2 nanoparticles	Ear inflammation	In vitro in HEK293T cells; in vivo in mice	Intravenous injection	Huang et al., 2016
Ceria-zirconia nanoparticles	Sepsis	In vitro in RAW264.7 cells; in vivo in mice/rats	Intravenous injection; intraperitoneal administration	Soh et al., 2017