Table 2.

Different organic nanoparticles with intrinsic antioxidant activities.

Types of organic nanoparticles		Applications	Evaluation models	Administration routes	References
Bilirubin-derived nanoparticles	BRNPs	Hepatic ischemia-reperfusion injury	In vitro in primary mouse hepatocytes; in vivo in mice	Intravenous injection	Kim J. Y. et al., 2017
		Asthma	In vivo in mice	Intravenous injection; intraperitoneal administration	Kim D. E. et al., 2017
		Inflammatory bowel disease	In vivo in mice	Intravenous injection	Lee et al., 2016a
		Pancreatic islet xenotransplantation	In vivo in mice	Intraperitoneal administration	Kim M. J. et al., 2017
	DOX@BRNPs Dox@bt-BRNPs cisPt@BRNPs	Tumor	In vivo in mice	Intravenous injection	Lee et al., 2016b, 2017, 2018
	HABN	Colitis	In vivo in mice	Oral administration	Lee et al., 2020
Melanin-like nanoparticles	MMPP	Acute kidney injury	In vitro in HEK293 cells; in vivo in mice	Intravenous injection	Sun et al., 2019
	PEG-MeNPs	Ischemic stroke	In vitro in Neuro 2A cells; in vivo in mice	Intravenous injection	Liu et al., 2017
	PDA-PEG/CP	Tumor	In vitro in HeLa cells	N/A	Zhu and Su, 2017
	Liposome-BSM	Tumor	In vivo in mice	Subcutaneous injection	Chu et al., 2016
	PDA NPs	Periodontal disease	In vivo in mice	Subgingival administration	Bao et al., 2018
	PDA	Acute peritonitis and acute lung injury	In vivo in mice	Intravenous injection; intraperitoneal administration	Zhao et al., 2018
Free radical-containing organic nanoparticles	RNPN and RNPO	Breast cancer	In vitro in MDA-MB-231 cells; in vivo in mice	Intravenous injection	Shashni and Nagasaki, 2018
	RNPO	Inflammatory bowel disease	In vivo in mice	Oral administration	Vong et al., 2012, 2014, 2015
	RNPN and RNPO	Colon cancer	In vitro in C-26 cells; in vivo in mice	Intravenous injection	Vong and Nagasaki, 2016
	RNPN and RNPO	Epidermoid cancers	In vitro in KB-3-1 and KB/MRP cells	N/A	Shashni et al., 2017
	RNPN	Radiation-induced organ dysfunctions	In vitro in RAW264.7 cells; in vivo in mice	Subcutaneous injection	Feliciano et al., 2017
	RNPN	Ischemia reperfusion injury	In vivo in mice	Intravenous injection	Yoshitomi et al., 2011
	RNPs	Nonalcoholic steatohepatitis	In vivo in mice	Intravenous injection	Eguchi et al., 2015
	RNPs	Neurological deficits	In vivo in mice	Intravenous injection	Chonpathompikunlert et al., 2012
Phenolic nanoparticles	HPOX	Asthma	In vitro in RAW264.7 cells; In vivo in mice	Intratracheal administration	Yoo et al., 2013
		Hindlimb ischemia	In vivo in mice	Intramuscular injection	Cho et al., 2015
		H2O2-associated inflammatory diseases	In vitro in RAW264.7 cells	N/A	Cho et al., 2012
	PVAX	Acute liver failure	In vitro in RAW264.7 cells; in vivo in mice	Intravenous injection	Ko et al., 2014
	PVO	Hepatic ischemia-reperfusion injure	In vivo in mice	Intravenous injection	Kang et al., 2016
Nanoparticles derived from functional cyclodextrin materials	Nanoparticles based on PBAP-conjugated cyclodextrin	Tumor	In vitro in B16F10 and RAW264.7 cells; in vivo in mice	Intravenous injection	Zhang et al., 2015
		Arterial restenosis	In vitro in rat VSMCs; in vivo in rats	Intravenous injection	Feng et al., 2016
		Inflammatory bowel disease	In vivo in mice	Oral administration	Zhang Q. et al., 2016
		Atherosclerosis	In vitro in RAW264.7 cells; in vivo in mice	Intravenous injection	Dou et al., 2017
		Abdominal aortic aneurysm	In vivo in mice	Intravenous injection	Cheng et al., 2018
		Peritonitis	In vitro in RAW264.7 cells; in vivo in mice	Intraperitoneal administration	Zhang et al., 2017
		Colitis-associated colon cancer	In vitro in C26 murine colon carcinoma cells; in vivo in mice	Oral administration	Zhang Q. et al., 2019
	LCD nanoparticles	Peritonitis, acute lung injury, and atherosclerosis	In vitro in neutrophils and macrophages; in vivo in mice	Intraperitoneal administration; intravenous injection	Guo et al., 2019
	TPCD nanoparticles	Peritonitis, acute lung injury, drug-induced organ toxicity, and atherosclerosis	In vivo in mice	Intraperitoneal administration; intravenous injection	Li et al., 2018; Wang et al., 2018
Other organic nanoparticles	PVA-C	Air pouch model	In vitro in BMSCs; in vivo in rats	Subcutaneous injection	Wu et al., 2019