Table 2.

Old classification of anthracycline-induced cardiotoxicity (7, 12–14).

Characteristics	Acute cardiotoxicity	Early-onset chronic cardiotoxicity	Late-onset chronic cardiotoxicity
Onset	During or within 2 weeks after AC treatment	Within 1 year after the completion of AC treatment	>1 year after the completion of AC treatment
Dose dependent	Unknown	Yes	Yes
Clinical features	Depression of myocardial contractility	Dilated/Hypokinetic cardiomyopathy	Dilated/Hypokinetic cardiomyopathy
Course	Usually reversible	Usually irreversible	Usually irreversible
		Refractory to traditional heart failure therapy	Refractory to traditional heart failure therapy
		Poor prognosis	Poor prognosis