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. 2020 Mar 24;11:1539. doi: 10.1038/s41467-020-15344-3

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 1 — a, b Chest computed tomography (CT) findings and CT scores of wild-type and TGFβ1 transgenic (TG) mice. n = 9 in WT without fibrosis, n = 6 in TGFβ1 TG without fibrosis and TGFβ1 TG with fibrosis. Bars indicate the means ± S.D. Statistical analysis by ANOVA with Tukey’s test. *p < 0.001. c The lung tissue Na⁺ was measured by microwave analysis/inductively coupled plasma mass spectrometry. Fibrotic lung tissues excised from wild-type and transforming growth factor (TGF)β1 TG mice with and without (n = 6) lung fibrosis. n = 9 in WT without fibrosis, n = 6 in TGFβ1 TG without fibrosis and TGFβ1 TG with fibrosis. Bars indicate the means ± S.D. Statistical analysis by Mann–Whitney U test. Statistical analysis by ANOVA with Tukey’s test. *p < 0.001. The source data underlying Fig. 1b, c are provided in the Source Data file.