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. 2020 Mar 24;11:1539. doi: 10.1038/s41467-020-15344-3

Fig. 8. Significant increase in corisin level in TGFβ1 TG mice with lung fibrosis and in patients with idiopathic pulmonary fibrosis.

Fig. 8

a, b Western blotting of corisin in lung tissue from wild-type and transforming growth factor (TGF)β1 transgenic (TG) mice performed as described under methods and the ratio of corisin to β-actin. Quantification was performed using ImageJ, a public domain image processing program. Each mouse group with n = 4. Bars indicate the means ± S.D. Statistical analysis by ANOVA with Tukey’s test. *p < 0.01, **p < 0.001. c Corisin was measured using a competitive enzyme immune assay as described under methods. Healthy controls, n = 8; all stable idiopathic pulmonary fibrosis (IPF) patients, n = 34; IPF patients with acute exacerbation, n = 14. Bars indicate the means ± S.D. Statistical analysis by ANOVA with Newman-Keuls test. *p < 0.05, **p < 0.001. d Analysis of bronchoalveolar lavage fluid levels of corisin in the same IPF patients before and after acute exacerbation, n = 14. Bars indicate the means. Statistical analysis by two-tailed Mann–Whitney U Test. **p < 0.001. The source data underlying a–d are provided in the Source Data file.