Table 1.
Inhibition of GABA-evoked ion current by PFOS or PFOA.
| Concentration (µM) | Low effective GABA concentration | High effective GABA concentration | |||
|---|---|---|---|---|---|
| % Inhibition | p-value | % Inhibition | p-value | ||
| PFOS | 0.01 | 4.8 ± 4.8 (4) | n.s | 7.6 ± 3.3 (4) | n.s |
| 0.1 | 15 ± 1.8 (4) | 0.002 | 33 ± 4.6 (4) | <0.0001 | |
| 1 | 90 ± 1.5 (3) | <0.0001 | 89 ± 0.9 (3) | <0.0001 | |
| 10 | 98 ± 1.2 (4) | <0.0001 | 100 ± 0 (3) | <0.0001 | |
| 100 | 100 ± 0 (4) | <0.0001 | 100 ± 0 (4) | <0.0001 | |
| PFOA | 0.01 | 0 ± 0 (4) | n.s. | 0.4 ± 0.5 (4) | n.s |
| 0.1 | 0 ± 0 (4) | n.s. | 0 ± 0 (3) | n.s | |
| 1 | 6 ± 0.4 (4) | n.s | 16 ± 0.4 (4) | <0.0001 | |
| 10 | 31 ± 1.9 (4) | <0.0001 | 58 ± 1.5 (4) | <0.0001 | |
| 100 | 83 ± 2.7 (4) | <0.0001 | 93 ± 2.7 (4) | <0.0001 | |
Mean percentage of inhibition of the current (± SEM (n)) induced during exposure to PFOS or PFOA. Inhibitions were compared to control and p-values are given; n.s.: non-significant.