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. 2020 Mar 24;10:5336. doi: 10.1038/s41598-020-62129-1

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Odds ratios (ORs) of CRC by (A) KRAS and BRAF mutation status and (B) MSI status per 1 SD increase in metabolic biomarkers. Estimated in 1010 cases and 1010 matched controls, adjusted for matching variables and smoking, occupational and recreational physical activity, alcohol intake, and BMI. Heterogeneity across molecular subtypes was tested with a likelihood ratio test, comparing a model in which the risk association could vary across subtypes to a model were all associations were held constant. Numbers (n) within subtypes represent complete cases, molecular data for the remaining cases were imputed.