Table 1.
Overview of Clinical Findings in All Animals.
| Animal | Baseline | Endpoint | |||||||
|---|---|---|---|---|---|---|---|---|---|
| Injection Site | Weight (kg) | mTS | Hindlimb Motor Deficits | Superficial Pain Response | Conscious Proprioception | Gastrointestinal Genitourinary | Weight (kg) | mTS | |
| 1 | R: ONC | 20.2 | 9 | Right | R: Delayed | R: Delayed | WNL | 20.4 | 8 |
| L: CTRL | |||||||||
| 2 | R: CTRL | 19.7 | 9 | Bilat | R: Absent | R: Absent | Urine Retention | 21.8 | 0 |
| L: ONC | L: Absent | L: Absent | |||||||
| 3 | R: ONC | 15.3 | 9 | Bilat | WNL | R: Absent | WNL | 16.4 | 3 |
| L: CTRL | L: Absent | ||||||||
| 4 | R: CTRL | 15.5 | 9 | Left | WNL | L: Delayed | WNL | 15.4 | 8 |
| L: ONC | |||||||||
| 5 | R: ONC | 21.6 | 9 | Right | R: Delayed | R: Absent | WNL | 21.1 | 8 |
| L: CTRL | |||||||||
| 6 | R: CTRL | 17.2 | 9 | Left | WNL | WNL | WNL | 18.1 | 8 |
| L: ONC | |||||||||
Abbreviations: R – right, L – left, ONC – oncogenic vectors, CTRL – control vectors, Bilat – bilateral, GI/GU – Gastrointestinal or Genitourinary, WNL – within normal limits, mTS – modified Tarlov Score.