Table 2.
Selected Chagas disease specific motifs and candidate antigens and epitopes.
| Motif | Candidate T. cruzi Antigen | Candidate Epitope | Sensitivity | Specificity |
|---|---|---|---|---|
| SP[YW]xI[FY] | Kinetoplast DNA-associated protein | SPYsIF | 62% | 100% |
| KAxLPE | Mucin-associated surface protein (MASP) | KAtLPE | 63% | 98% |
| KxEGx[FY]xG | Trans-sialidase | KeEGgFtG | 43% | 99% |
| ETxIPxE | Trans-sialidase, FL-160-1 epitope | ETeIPsE | 42% | 98% |
| PDxFSx[ITV] | Trans-sialidase | PDsFSsT | 42% | 99% |
| GxAAAxxK | Surface antigen 2 (CA-2) (51 repeats) | GqAAAgdK | 58% | 100% |
| [FW]KPWE & EGxKxWE | Metacaspase | EGFKPWE | 45% 32% | 96% 99% |
| [AS]EAxAxxK | Mucin-associated surface protein (MASP) (2 repeats) | AEAaAkaK | 27% | 99% |
| KxxGExxGT | Mucin TcMUCII | KstGEatGT | 13% | 99% |
| RxxWYx[ILV]V | Mucin-associated surface protein (MASP) | RhqWYaVV | 28% | 100% |
| AGxKPx[AE] | Trans-sialidase (11 repeats) | AGpKPaE | 33% | 100% |
| GDKPxxxC | Surface protease GP63 | GDKPsswC | 47% | 98% |
| NExTWxxV | ATPase protein | NEeTWppV | 22% | 100% |
| HYEWA | Lanosterol synthase | HYEWA | 17% | 100% |
| Yx[AP]Vxxx[AS]Y | Microtubule-associated protein (19 repeats) | YrPVdpsAY | 55% | 100% |