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. 2020 Mar 24;11:1531. doi: 10.1038/s41467-020-15270-4

Fig. 5. Hypothetic models of VAMP2 conformations and engagement in SNARE complex assembly for neurotransmitter release.

Fig. 5

The extravesicular domain of VAMP2 adopts distinctive conformations in different membrane regions. On the cholesterol-rich microdomains, it is less associated with SV membrane and thus more active to engage in calcium-evoked SNARE assembly and neurotransmitter release. In contrast, in other regions of SV membrane, it tends to hibernate on the membrane with an increased content of α-helical conformation which is relatively inactive in SNARE assembly.