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. 2020 Mar 24;10:5302. doi: 10.1038/s41598-020-62269-4

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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In vivo MRI of nanodrugs delivery. (A) Experimental flowchart of diabetes induction using streptozotocin (STZ), intra-pancreatic ductal injection of the nanodrugs, magnetic resonance imaging (MRI) and post-injection testing. (B) Gross anatomic images of the pancreatic tissue (green arrow) pre‐ and post- intra-pancreatic ductal injection. Note the pancreatic area turning dark post injection, consistent with diffusion of the nanoparticle solution. (C) Representative MRI of the nanodrug delivery to the pancreas (MN-miRNA is shown). Axial T2‐weighted images showing loss of signal intensity in the pancreatic tissue (red outline) of diabetic animals 72 hours post injection.