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. 2020 Mar 24;10:5302. doi: 10.1038/s41598-020-62269-4

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fluorescence microscopy of consecutive frozen pancreatic sections from STZ-induced diabetic mice injected with MN-miRNA, MN-ASO, MN-miRNAscr and MN-ASOscr. Animals injected with MN-miRNA showed higher insulin expression in pancreatic islets (top: green, insulin; red, Cy5.5; blue, cell nucleus) compared to the animals injected with MN-ASO or control nanodrugs. These animals also showed downregulated PTEN expression in their islets (middle: green, PTEN; red, Cy5.5; blue, cell nucleus) compared to the animals injected with MN-ASO or control nanodrugs. Finally, there was a notably higher cell proliferation in the islets of these animals compared to controls (bottom green, Ki67; red, Cy5.5; blue, cell nucleus); Magnification bar = 40 μm. All experiments were performed in triplicate.