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. 2020 Mar 24;10:5302. doi: 10.1038/s41598-020-62269-4

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Therapeutic effect of the nanodrugs and toxicity testing in STZ-induced diabetic mice. (A) Results of IPGTT in mice injected with MN-ASO, MN-miRNA and controls. There was a significant difference in the glucose disposal curves between the group injected with MN-miRNA and the other three groups. These mice showed significantly lower blood glucose levels at 60 mins after the challenge compared to the other groups (n = 5, *P < 0.05). (B) Blood chemistry panel of diabetic animals (n = 5) injected with miR-216-specific nanodrug showed no indication of hepatic, renal or pancreatic toxicity. Albumin (ALB), alanine aminotransferase (ALT), total bilirubin (TBIL), blood urea nitrogen (BUN), creatinine (CREA), amylase (AMYL), lipase (LIPA).