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. 2020 Mar 24;10:5313. doi: 10.1038/s41598-020-62140-6

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Effect of let-7-downregulated hADSC-EVs to HUVECs on the proliferation, migration and tube formation on Matrigel. (A) Image and (B–D) semi-quantitative EdU, transwell migration and tube formation assays of HUVECs with and without hADSC-EVs, hypoxic hADSC-EVs or LIN28B transfected hADSC-EVs. The results indicated that, compared with that of normal hADSC-EVs, blocking of let-7 impair the abilities of promoting migration and tube formation of hADSC-EVs, but has no significant effect on the ability to promote HUVEC proliferation. Data are presented as the mean ± SD (n = 3). *P < 0.05, **P < 0.01. Scale bar in EDU test: 100 μm. Scale bar in transwell and tube formation assays: 1 mm.