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. 2020 Mar 24;10:5313. doi: 10.1038/s41598-020-62140-6

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Detection of the let-7/AGO1/VEGF signalling pathway in a mouse model of fat grafting (n = 12). (A) The fat grafts harvested at post-grafted week 12. (B) The volume retention rate of fat grafts co-transplanted by LIN28B-hADSC-EVs was significantly decreased at post-grafting week 12, compared with grafts co-transplanted by normal hADSC-EVs, but was still higher than grafts co-transplanted by PBS. (C) The results of qRT-PCR for AGO1 mRNA expression of fat grafts at post-grafting day 3. (D) The results of qRT-PCR for VEGF mRNA expression of fat grafts at post-grafting day 3. (E) The results of ELISA for VEGF protein concentration of fat grafts at post-grafting day 3. Data are presented as the mean ± SD (n = 12). *P < 0.05, **P < 0.01.