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. 2020 Mar 24;10:5321. doi: 10.1038/s41598-020-62139-z

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Bacterial growth and tumor spheroid viability kinetics in BSCCs. (A) F. nucleatum 16s rRNA gene qPCR from the BSCC model over a 48 h period. Results are shown as 16s rDNA copies over time for BSCCs with F. nucleatum strains 23726 (blue) and 25586 (red). (B) Tumor spheroid cytotoxicity over 48 h after inoculation with F. nucleatum. Increased fluorescence is indicative of increased cytotoxicity in the dye exclusion assay. Results show BSCCs with F. nucleatum 23726 (blue), 25586 (red), lysis solution treatment (white), or vehicle control (black). Data represent the mean and standard deviation of at least three biological replicates.