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. 2020 Mar 24;10:5321. doi: 10.1038/s41598-020-62139-z

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Longitudinal metabolomic analysis of BSCCs. (A) Hierarchical clustering of differentially abundant metabolites (p < 0.05) in BSCCs. Time (in hours) after BSCC inoculation is shown for each treatment below heat map. (B) PCA of the global metabolome detected using Q-TOF LC/MS. Each plot represents a timepoint after BSCC inoculation. (C) Mass spectral abundance of several metabolites in BSCCs at four timepoints (*p < 0.01, one-way ANOVA with Dunnett’s multiple comparisons test).