Table 3.
OCTA comparison between eyes of SSc patients and controls
| Variable | SSc | Control | p value |
|---|---|---|---|
| Mean ± SD | Mean ± SD | ||
| FAZ area(mm2) (in SCP) | 0.54 ± 0.13 (0.28−0.95) | 0.51 ± 0.16 (0.30−0.90) | 0.235 |
| FAZ area(mm2) (in full retina) | 0.31 ± 0.10 (0.07−0.55) | 0.27 ± 0.13 (0.09−0.57) | 0.099 |
| Perimeter (mm) | 2.12 ± 0.35 (1.12−2.85) | 1.95 ± 0.48 (1.18−2.90) | 0.051 |
| Acircularity index | 1.10 ± 0.03 (1.04−1.20) | 1.09 ± 0.02 (1.05−1.13) | 0.612 |
| Foveal density (%) | 54.23 ± 3.96 (46.78−61.19) | 54.68 ± 3.91 (44.02−62.14) | 0.593 |
| Vessel density SCP% | |||
| Whole image | 49.79 ± 3.47 (42.60−56.30) | 51.49 ± 2.89 (43.10−56.50) | 0.013* |
| Superior-hemi | 49.80 ± 3.65 (41.70−56.60) | 51.30 ± 2.84 (43.20−55.80) | 0.033* |
| Inferior-hemi | 49.78 ± 3.40 (42.30−56.10) | 51.66 ± 3.08 (42.90−57.20) | 0.007* |
| Fovea | 18.20 ± 5.91 (2.10−34.60) | 22.20 ± 7.18 (3.70−36.40) | 0.005* |
| Parafovea | 51.45 ± 4.25 (42.90–58.00) | 54.23 ± 2.76 (46.10−58.30) | P < 0.001* |
| Temporal | 51.76 ± 4.05 (41.70−57.80) | 54.18 ± 2.95 (47.10−58.40) | 0.002* |
| Superior | 51.79 ± 6.22 (35.70−59.00) | 55.00 ± 3.37 (46.50−59.90) | 0.003* |
| Nasal | 50.64 ± 3.97 (39.60−58.30) | 53.26 ± 3.05 (47.10−60.00) | p < 0.001* |
| Inferior | 52.15 ± 4.61 (43.50−60.10) | 54.03 ± 3.37 (43.50−60.00) | 0.029* |
| Perifovea | 50.42 ± 3.75 (42.90−56.30) | 52.21 ± 3.27 (42.40−57.90) | 0.018* |
| Temporal | 46.54 ± 3.68 (37.20−57.50) | 48.86 ± 3.63 (38.20−57.90) | 0.010* |
| Superior | 50.44 ± 4.20 (40.70−57.10) | 52.18 ± 4.20 (40.70−67.10) | 0.052 |
| Nasal | 54.34 ± 3.43 (44.40−61.20) | 56.01 ± 3.18 (48.00−61.40) | 0.019* |
| Inferior | 50.70 ± 3.88 (43.20−57.50) | 52.52 ± 3.87 (42.60−59.20) | 0.028* |
| Vessel density DCP % | |||
| Whole image | 51.56 ± 6.52 (39.10−64.10) | 52.44 ± 5.43 (38.70−62.10) | 0.479 |
| Superior-hemi | 52.00 ± 6.85 (39.70−64.10) | 52.98 ± 5.74 (37.50−61.00) | 0.446 |
| Inferior-hemi | 50.91 ± 8.00 (36.80−64.20) | 51.85 ± 5.29 (20.80−48.50) | 0.467 |
| Fovea | 34.61 ± 6.38 (15.50−47.90) | 38.16 ± 8.44 (39.90−63.40) | 0.044* |
| Parafovea | 55.57 ± 4.55 (46.10−63.00) | 55.87 ± 4.05 (43.00−62.00) | 0.744 |
| Temporal | 56.06 ± 4.80 (47.70−64.00) | 56.58 ± 3.09 (50.40−61.30) | 0.398 |
| Superior | 55.34 ± 5.06 (45.60−63.50) | 55.09 ± 3.89 (48.00−60.60) | 0.146 |
| Nasal | 56.06 ± 4.49 (47.70−64.80) | 56.75 ± 3.94 (48.10−64.70) | 0.437 |
| Inferior | 54.17 ± 5.21 (40.70−62.00) | 53.74 ± 4.90 (39.30−60.90) | 0.684 |
| Perifovea | 52.68 ± 7.12 (38.00−65.60) | 54.13 ± 5.78 (38.50−64.20) | 0.294 |
| Temporal | 54.73 ± 6.29 (43.00−66.10) | 56.52 ± 4.72 (44.20−64.50) | 0.130 |
| Superior | 52.53 ± 8.03 (35.90−65.50) | 53.66 ± 6.80 (34.00−65.70) | 0.475 |
| Nasal | 52.30 ± 7.58 (35.30−65.50) | 53.37 ± 6.28 (38.60−64.90) | 0.468 |
| Inferior | 51.45 ± 8.18 (34.90−65.50) | 52.96 ± 6.44 (34.60−62.10) | 0.335 |
| CCP choriocapillaris flow area mm2 | |||
| 1 mm | 2.13 ± 0.12 (1.93−2.68) | 2.11 ± 0.12 (1.65−2.38) | 0.343 |
| 2 mm | 8.70 ± 0.30 (8.03−9.33) | 8.63 ± 0.43 (7.16−9.63) | 0.396 |
| 3 mm | 19.93 ± 0.66 (18.48−21.40) | 19.92 ± 0.85 (17.41−21.96) | 0.933 |
All data are presented as the means ± SD
OCTA optical coherence tomography angiography, FAZ foveal avascular zone, SCP superficial capillary plexus, DCP deep capillary plexus
*The value was statistically significant (p < 0.05)