Table 2.
Liver and serum antioxidant enzymes in control and treated groups (n = 8)
| Parameter#\group | Control | Cis | CMFE | CME 300 + Cis | CME 700 + Cis | P value |
|---|---|---|---|---|---|---|
| Serum antioxidant enzymes level | ||||||
| AST (u/l) | 190.67 (12.95) | 142.50 (24.30) | 156.33 (16.42) | 185.17 (44.23) | 185.00 (50.15) | 0.065 |
| ALT (u/l) | 110.83 (15.27) | 66.50 (10.89)£ | 79.50 (10.48) | 116.33 (19.96) | 114.20 (32.95) | < 0.001 |
| ALP (u/l) | 469.67 (140.15) | 145.17 (25.54)§ | 384.00 (82.87) | 328.83 (193.70) | 331.60 (102.13) | 0.003 |
| GGT (nmol/mg prot/min) | 4.33 (.51) | 7.67 (3.38) | 5.83 (2.63) | 5.17 (1.32) | 5.80 (2.49) | 0.181 |
| Liver antioxidant enzymes activity | ||||||
| SOD (U/mL) | 36.36 (3.22) | 26.07 (5.89)ŧ | 37.35 (4.38) | 37.61 (5.35) | 31.64 (9.85) | 0.011 |
| GPx (U/mL/100) | 71 (23) | 56 (5) | 80 (14) | 63 (13) | 62 (17) | 0.130 |
| TAC (µmol trolox equivalent/mL) | 170 (2) | 155 (5)ε | 161 (3) | 171 (5) | 173 (10) | 0.002 |
| CAT (nmol/min/mL) | 42.30 (8.82) | 27.17 (9.75) | 37.05 (11.13) | 38.27 (6.84) | 38.69 (8.18) | 0.086 |
| MDA (nmol/mL) | 9.88 (1.51) | 18.15 (8.04)η | 8.71 (4.08) | 8.06 (1.82) | 8.62 (1.16) | 0.002 |
AST Aspartate aminotransferase, ALT alanine aminotransferase, ALP alkaline phosphatase, GGT gamma-glutamyl transferase, SOD superoxide dismutase, GPx glutathione peroxidase, TAC total antioxidant capacity, CAT catalase, MDA malondialdehyde
#Data are expressed as Mean (SD) and P.value based on Anova followed by tuky post hoc test
£P value < 0.05 compared with control, CDDP300, and CDDP700 group
§P value < 0.05 compared with control and CMFE group
ŧP value < 0.05 compared with control, CME, and CDDP300 group
εP value < 0.05 compared with control, CDDP300 and CDDP700 group
ηP value < 0.05 compared with control, CME, CDDP300, and CDDP700 group