Table 3.

Liver histopathologic changes index in control and treated groups (n = 8)

Parameter	Control	CMFE	Cis	CMFE300 + Cis	CMFE700 + Cis
Necrosis	0.00	0.50	1.40*	0.83	0.50
Inflammation	0.00	0.17	0.60	0.17	0.00
Fatty change	0.00	0.33	1.40*	0.33	0.33
Congestion and hemorrhage	0.00	0.50	1.80*	0.83	0.67
Total pathologic changes	0.00	1.50	5.20*	2.17*	1.50

CMFE Cornus mas fruit hydromethanolic extract, Cis cisplatin. The results are expressed as means of scores

*Significantly different when compared with the control group (P < 0.01)