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Structural features of TRPC6 channel. (A) Transmembrane protein TRPC6 contains six TDs, four NH2-terminal ARDs, and a COOH-terminal TRP domain. (B) S1–S6 are TDs. The pore region of TRPC6, situated between the S5 and S6, allows the passage of cations. TRP: transient receptor potential; TRPC6: transient receptor potential canonical channel 6; TD: transmembrane domain; ARD: ankyrin repeat domain; S1–S6: S1–S6 are the abbreviations of the first to sixth transmembrane domains.
