Table 2.
Characteristics of female subjects with differential expressions of serum TPOAb and TgAb.
|
TPOAb−TgAb− (n = 8,000) |
TPOAb+TgAb− (n = 1,202) |
TPOAb−TgAb+ (n = 1,588) |
TPOAb+TgAb+ (n = 1,372) |
|
|---|---|---|---|---|
| Age, years | 45 (34–56) | 47 (37–57)* | 45 (32–55) | 44 (33–54) |
| Urban inhabitant | 4,151 (51.9) | 598 (49.8) | 847 (53.3) | 706 (51.5) |
| Han nationality | 7,129 (89.1) | 1,065 (88.6) | 1,421 (89.5) | 1,257 (91.6)# |
| College and above education | 2,218 (27.7) | 275 (22.9)# | 458 (28.8) | 389 (28.4) |
| Income per year ≥ 30,000 yuan | 4,114 (51.4) | 598 (49.8) | 822 (51.8) | 715 (52.1) |
| Smoking | 275 (3.4) | 50 (4.2) | 37 (2.3) | 44 (3.2) |
| With family history of thyroid disease | 402 (5.1) | 92 (7.7)# | 96 (6.1) | 120 (8.8)# |
| Post menopause | 2,960 (37.0) | 506 (42.1)# | 563 (35.5) | 483 (35.2) |
| Consumption of iodized salt | 7,633 (95.4) | 1,149 (95.6) | 1,521 (95.8) | 1,306 (95.2) |
| UIC, μg/L | ||||
| <100 | 1,611 (20.1) | 265 (22.0)# | 337 (21.2) | 298 (21.7) |
| 100–199 | 3,187 (39.8) | 522 (43.4)# | 619 (39.0) | 545 (39.7) |
| 200–299 | 1,779 (22.2) | 235 (19.6)# | 335 (21.1) | 288 (21.0) |
| ≥300 | 1,423 (17.8) | 180 (15.0)# | 288 (21.0) | 241 (17.6) |
| TSH, mIU/L | 2.24 ± 0.89 | 2.35 ± 0.95* | 2.36 ± 0.93* | 2.56 ± 0.95* |
| Goiter | 79 (1.0) | 20 (1.7) | 22 (1.4) | 49 (3.6)# |
| Thyroid nodule | 1,947 (24.3) | 313 (26.0) | 345 (21.7) | 313 (22.8) |
| BMI, kg/m2 | 23.57 ± 3.73 | 23.71 ± 3.62 | 23.52 ± 3.70 | 23.71 ± 3.65 |
| WC, cm | 80.25 ± 10.39 | 80.83 ± 10.10 | 80.38 ± 10.27 | 80.23 ± 10.47 |
| SBP, mmHg | 123.34 ± 20.02 | 125.16 ± 20.58 | 122.44 ± 19.74 | 122.21 ± 19.68 |
| DBP, mmHg | 76.34 ± 11.71 | 76.98 ± 12.30 | 76.01 ± 11.38 | 76.17 ± 12.58 |
| FPG, mmol/L | 5.34 ± 1.35 | 5.4 ± 1.45 | 5.24 ± 1.15* | 5.28 ± 1.01 |
| 2 hPG, mmol/L | 6.64 ± 2.69 | 6.77 ± 2.70 | 6.47 ± 2.48 | 6.46 ± 2.37 |
| HbA1c, % | 5.53 ± 1.10 | 5.60 ± 1.06 | 5.45 ± 0.98 | 5.49 ± 0.94 |
| TG, mmol/L | 1.10 (0.77–1.64) | 1.09 (0.78–1.63) | 1.09 (0.76–1.59) | 1.06 (0.76–1.61) |
| TC, mmol/L | 4.75 ± 1.10 | 4.84 ± 1.14 | 4.71 ± 1.12 | 4.72 ± 1.07 |
| LDL-C, mmol/L | 2.78 ± 0.91 | 2.85 ± 0.96 | 2.82 ± 1.03 | 2.79 ± 0.96 |
| HDL-C, mmol/L | 1.6 ± 0.58 | 1.62 ± 0.63 | 1.64 ± 0.62* | 1.58 ± 0.53 |
Data are presented as the mean ± standard deviation for continuous variables or as n (%) for categorical variables.
Age and TG are presented as median (P25-P75).
*
P < 0.05 as compared with that of TPOAb−TgAb− group.
#
P < adjusted cut-off value of P due to the multiple comparisons for statistical significance (0.05/3 = 0.017) in chi-square test.