Table 5.

Summary of the studies related to TPOAb, TgAb, and metabolic disorders of glucose and lipids.

	References	Subjects	Grouping for analysis	Findings
1	Raposo et al. (8)	① 281 females and 205 males ② ≥18 years old ③ with euthyroidism, hyperthyroidism or hypothyroidism	① grouping as TPOAb+, TgAb+, TPOAb+, and/or TgAb+ (TPOAb+/TgAb+), both TPOAb+, and TgAb+ (TPOAb+ TgAb+) ② not stratified by gender	① TPOAb positivity was negatively related to the prevalence of metabolic syndrome and its TG component while TgAb had no association. ② in logistic regression model, only age and sex were adjusted.
2	Chen et al. (6)	① 5,134 females and 3,948 males from East China ② ≥18 years old ③ with euthyroidism	① grouping as TPOAb+/TgAb+, both TPOAb-, and TgAb- (TPOAb-TgAb-) ② stratified by gender	① TPOAb+/TgAb+ was related to an increased risk for central obesity, hyperlipidemia, and metabolic syndrome in females, but not in males. ② in logistic regression model, age, smoking history, TSH, BMI, and menopausal status in women were adjusted. ③ linear regression showed that B was −0.021 between TPOAb+/TgAb+ and FPG level (P = 0.055) in men while B was 0.032 between TPOAb+/TgAb+ and TG level (P = 0.052) in women.
3	Liu et al. (14)	① 4,134 non-obese females and 1,474 non-obese males from Beijing Chao-Yang Hospital ② averagely aged 45–46 years old ③ with euthyroidism	① grouping as TPOAb+/TgAb+ and TPOAb-TgAb- ② not stratified by gender	① blood TG and FBG levels were lower in TPOAb+/TgAb+ group (P = 0.054 and 0.075, respectively). ② serum TPOAb titer positively correlated with the levels of TC, TG, HOMA-IR and hsCRP in non-obese individuals, but TgAb titer did not. ③ no regression analysis was performed between TPOAb and lipids.
4	Sarfo-Kantanka et al. (15)	① 178 females and 124 males with T2DM; 181 females and 129 males as controls ② 40–80 years old ③ with euthyroidism, hyperthyroidism or hypothyroidism	① grouping as TPOAb+/TgAb+ and TPOAb-TgAb- ② not stratified by gender	① TPOAb+/TgAb+ in T2DM patients may be related to the increased risk of hypercholesterolemia and poor glycemic control. ② in logistic regression model, age, sex and thyroid functions were adjusted.
5	Kang et al. (16)	① 1,607 subjects (male: female 1:3.7) ② 35–65 years old ③ with euthyroidism	① grouping as TPOAb+ and TPOAb- (TgAb not measured) ② not stratified by gender	① TPOAb positivity was associated with the increased levels of blood TC, LDL-C and HDL-C, but not TG. ② no regression analysis was performed.
6	Amouzegar et al. (17)	① 1,172 females and 1,531 males ② ≥20 years old ③ with euthyroidism	① grouping as TPOAb+ and TPOAb- (TgAb not measured) ② stratified by gender	① no differences were observed in HOMA-IR, blood lipids, BMI, BP, or FBG between TPOAb+ and TPOAb- groups. ② no regression analysis was performed.
7	Agbaht et al. (7)	① 484 females and 64 males with obesity ② 35–51 years old ③ with euthyroidism or hypothyroidism	① grouping as obesity with and without metabolic syndrome ② TgAb not measured ③ not stratified by gender	① serum TPOAb level was not correlated with the occurrence of metabolic syndrome. ② in regression model, age, sex, TSH, HOMA-IR, BMI, family history, and smoking were adjusted.
8	Mazaheri et al. (18)	① 98 females and 14 males ② 41.8 ± 12.8 years old ③ with euthyroidism due to levothyroxine replacement therapy.	① grouping as TPOAb negative (<80 IU/ml), positive (80–1,000), highly positive (>1,000) ② TgAb not measured ③ not stratified by gender.	① those subjects with highly positive TPOAb may have higher serum insulin and lower HDL-c levels when BMI at same. ② no regression analysis was performed.
9	Topaloglu et al. (19)	① 66 premenopausal females ② 17–50 years old ③ with euthyroidism	① grouping as TPOAb+/TgAb+ and TPOAb- TgAb- ② no males included	① both serum TPOAb and TgAb levels positively correlated with blood TC, LDL-C, and negatively correlated with HDL-C, and serum TgAb was also positively associated with TG level. ② no regression analysis was performed.
10	Tamer et al. (20)	① 334 females ② premenopausal stage ③ with euthyroidism or hypothyroidism	① grouping as TPOAb+/TgAb+ and TPOAb- TgAb- ② no males included	① serum TPOAb level positively correlated with TG concentration and waist circumferences, and negatively with HDL-C; serum TgAb also positively correlated with TG and non-HDL-C concentrations. ② no regression analysis was performed.
11	Wells et al. (21)	① 130 females and 58 males ② ≥40 years old ③ with subclinical hypothyroidism	① grouping as TPOAb+ and TPOAb- (TgAb not measured) ② not stratified by gender	① TPOAb positivity may not be related to the increased blood lipid levels in the patients with subclinical hypothyroidism. ② no regression analysis was performed.
12	The current study	① 12,162 females and 5,802 males from 31 provinces of mainland China ② ≥18 years old ③ with euthyroidism	① grouping as TPOAb-TgAb-, TPOAb+TgAb-, TPOAb-TgAb+, TPOAb+TgAb+ ② stratified by gender	① serum TgAb single positivity may imply a reduced risk of IFG in men and of hypertriglyceridemia in women. ② in logistic regression model, age, nationality, location, education level, family income, smoking, family history of thyroid diseases, menopausal status (in women), urinary iodine, BMI, TSH, thyroid nodule and goiter were all adjusted.