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. 2020 Mar 18;11:291. doi: 10.3389/fphar.2020.00291

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Copyright © 2020 Liang, Yu, Huang and Yen.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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(A) Experimental protocols for evaluating the efficacy of luteolin on murine CD4+ cell polarization. (B) Pre-treatment of luteolin reduced the percentage of CD4+ IL-4-secreting cells. *P < 0.05 vs. T_H2. (C) Experimental protocols for evaluating the efficacy of luteolin on murine naïve CD4+ cell polarization. (D) STAT6 and GATA3 protein expression of mouse naïve CD4+ cells were detected by western blot. pSTAT6 = phosphorylated (active) STAT6 protein; tSTAT6 = total STAT6 protein.