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. 2020 Mar 18;11:291. doi: 10.3389/fphar.2020.00291

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Copyright © 2020 Liang, Yu, Huang and Yen.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Luteolin inhibited CD4+IL-4+ cells expression of PBMCs isolated from HDM-AR or non-AR patients. (A) The protocol for human PBMCs pre-treatment with serial concentrations of luteolin and dexamethasone. Decreased percentage of CD4+ IL-4-secreting cells in PBMCs of (B) HDM allergic and (C) HDM non-allergic subjects after pretreatment with luteolin or dexamethasone. NC = negative control (medium without HDM); PC = positive control (medium with HDM); LO & Dex = pretreated with luteolin or dexamethasone, cultured in medium with HDM. ^#P < 0.05 vs. NC group. *P < 0.05 vs. PC group.