Fig. 3.

Longer NADH fluorescence lifetimes associated with focal GBMs correlate with improved survival in mice. H&E stains, left, coupled with Vimentin, right differentiate between (a) focal xenografts and (b) invasive xenografts. (c) Kaplan–Meier curve showing that mice with less-invasive xenografts had improved survival (log-rank test, $p=0.0008$), (d) which correlated significantly (log-rank test, $p<0.0001$) to longer NADH fluorescence lifetimes. There were significant differences (log-rank test, $p<0.0001$) between the amount of longer-lived fluorescence lifetime of NADH ($a_2\%$) between normal, less-invasive, and invasive xenografts that correlated with survival.