Table 1. Baseline Characteristics for Unadjusted Enrolled and Propensity Score–Matched Patients With or Without HMT Exposure.
| Characteristic | Unadjusted cohort | Propensity score–matched cohorta | ||||
|---|---|---|---|---|---|---|
| Patients, No. (%) | P Value | Patients, No. (%) | P value | |||
| HMT (n = 18 126) | No HMT (n = 39 717) | HMT (n = 17 878) | No HMT (n = 17 878) | |||
| Age, y | ||||||
| 45-49 | 660 (3.6) | 1701 (4.3) | <.001 | 647 (3.6) | 820 (4.6) | <.001 |
| 50-54 | 709 (3.9) | 1871 (4.7) | 686 (3.8) | 833 (4.7) | ||
| 55-59 | 913 (5.0) | 2184 (5.5) | 893 (5.0) | 966 (5.4) | ||
| 60-64 | 1123 (6.2) | 2504 (6.3) | 1103 (6.2) | 1140 (6.4) | ||
| 65-69 | 4618 (25.5) | 10040 (25.3) | 4557 (25.5) | 4552 (25.5) | ||
| 70-74 | 4426 (24.4) | 8493 (21.4) | 4373 (24.5) | 3852 (21.6) | ||
| 75-79 | 2930 (16.2) | 6083 (15.3) | 2899 (16.2) | 2709 (15.2) | ||
| 80-84 | 1699 (9.4) | 3758 (9.5) | 1686 (9.4) | 1647 (9.2) | ||
| 85-89 | 320 (1.8) | 767 (1.9) | 314 (1.8) | 333 (1.9) | ||
| ≥90 | 728 (4.0) | 2316 (5.8) | 720 (4.0) | 1026 (5.7) | ||
| Race/ethnicity | ||||||
| Unknown | 2051 (11.3) | 4762 (12.0) | .04 | 1995 (11.2) | 2208 (12.4) | .01 |
| White | 13 642 (75.3) | 29 261 (73.7) | 13 443 (75.2) | 13 105 (73.3) | ||
| Black | 2000 (11.0) | 4574 (11.5) | 1969 (11.0) | 2085 (11.7) | ||
| Other | 151 (0.8) | 318 (0.8) | 149 (0.8) | 140 (0.8) | ||
| Asian | 95 (0.5) | 213 (0.5) | 93 (0.5) | 99 (0.6) | ||
| Hispanic | 200 (1.1) | 481 (1.2) | 198 (1.1) | 203 (1.1) | ||
| North American Native | 32 (0.2) | 63 (0.2) | 31 (0.2) | 38 (0.2) | ||
| Comorbidities | ||||||
| Type 2 diabetes | 1079 (6.0) | 2188 (5.5) | .03 | 998 (5.6) | 1030 (5.8) | .48 |
| CVD | 374 (2.1) | 995 (2.5) | .01 | 370 (2.1) | 423 (2.4) | .06 |
| Hypertension | 2459 (13.6) | 5500 (13.9) | .37 | 2423 (13.6) | 2438 (13.6) | .83 |
| CKD | 391 (2.2) | 987 (2.5) | .02 | 388 (2.2) | 417 (2.3) | .32 |
| Stroke | 355 (2.0) | 904 (2.3) | .02 | 349 (2.0) | 399 (2.2) | .07 |
| COPD | 184 (1.0) | 569 (1.4) | <.001 | 183 (1.0) | 235 (1.3) | .01 |
| Charlson Comorbidity Index | ||||||
| 0-4 | 14 174 (78.2) | 30 654 (77.2) | <.001 | 13 982 (78.2) | 14 536 (81.3) | <.001 |
| 5-10 | 3647 (20.1) | 8077 (20.3) | 3599 (20.1) | 3068 (17.2) | ||
| ≥11 | 280 (1.5) | 869 (2.2) | 297 (1.7) | 274 (1.5) | ||
Abbreviations: CKD, chronic kidney disease; COPD, chronic obstructive pulmonary disease; CVD, cardiovascular disease; HMT, hormone-modulating therapy.
a
Adjusted for history of stroke and COPD before the diagnosis of breast cancer.