Figure 1.

Renin Expression Is Upregulated in the Keratinocytes of OLP

(A) Real-time PCR quantification of renin in the oral mucosal epithelial layer, n = 14 each group.

(B and C) Western blot analysis (B) and densitometric quantitation (C) of renin in epithelial layer of oral mucosa, n = 14 each group.

(D) Renin immunostaining in the oral tissues of healthy controls and OLP patients.

(E and F) Real-time PCR quantification of renin in HOKs challenged by anti-CD3/28-activated CD4⁺ T cells (E) or 100 ng/mL LPS (F) for 0, 2, 4, 8 h, n = 3.

(G and H) Western blot determination of renin in HOKs challenged by anti-CD3/28-activated CD4⁺ T cells (G) or 100 ng/mL LPS (H) for different time points as shown, n = 3.

∗p < 0.05, ∗∗p < 0.01, ∗∗∗p < 0.001 versus corresponding control. Data were shown as means ± SD. Two-tailed Student's t test was used.