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. 2020 Feb 6;35:100958. doi: 10.1016/j.molmet.2020.02.001

Figure 7.

Figure 7

Loss of Klf6 in the β-cell Increases Dedifferentiated Phenotype Upon S961 Treatment. (a) Differential gene expression based on RNA-sequencing performed on islets (n = 8) harvested from Ctrl and βKlf6KO mice treated with S961 for 2 days. Data are represented as fold change of mRNA of specific genes. (b) RT-PCR of islets harvested from mice treated with S961 for a 7-day period (n = 5). Two-tailed unpaired Student's t-test. Error bars represent SEM. (c) Immunofluorescence of insulin, (d) Glut2 and (e) chromogranin A in Ctrl and βKlf6KO pancreata following saline or S961 treatment for 7 days (n = 4). Scale bar: 50 μm.