Table 1.

Comparative Species Sensitivity to Rintatolimod

Species	MTD (mg/kg)∗	Dosing in relevant toxicological study
Rabbit	1.25	i.v. daily × 5 days (0, 1.25, 2.5, 5, and 10 mg/kg per dose)
Dog	10	i.v. twice weekly × mg/kg per dose
Rat	12.5	i.v. twice weekly × 13 weeks (0, 12.5, 30, and 75 mg/kg per dose)
Cynomolgus monkey	100	i.v. twice weekly × 4 weeks (0, 12.5, 25, 50, 100, and 200 mg/kg per dose)

^∗The MTD is defined as the highest dose with no observed mortality or moribund toxicity.