Table 5.

Cytokine Responses from Baseline in Patients with Chronic Fatigue Syndrome Enrolled in Two Clinical Trials of Rinitatolimod (Ampligen)

Cytokine	AMP-511 open-label study, 4 hours after rinitatolimod infusion		AMP-516 placebo-controlled study, week 32
	Rinitatolimod (n = 14)		Rinitatolimod (n = 40)		Placebo (n = 36)
	Means ± SD	Median	Means ± SD	Median	Means ± SD	Median
IFN-γ (pg/mL)	3.76 ± 26.14	0.00	1.00 ± 8.86	0.00	11.03 ± 63.44	0.00
TNF-α (pg/mL)	1.21 ± 3.30	0.00	17.03 ± 94.73∗	1.00	1.56 ± 66.30	0.14
IL-12p70 (U/mL)	1.22 ± 2.94	0.00	3.51 ± 22.28	−0.33	0.39 ± 3.68	−0.02
IL-10 (pg/mL)	0.08 ± 0.39	0.00	4.04 ± 24.06	0.05	−0.04 ± 0.63	0.00

The 400-mg infusions providing an approximately 6 mg/kg average dosing.

^∗High means and SD values were secondary to one patient with a value of 500. Removal of this patient results in a mean value of 4.6.