Comparison 1. Amantadine or rimantadine compared to placebo or acetaminophen in the treatment of influenza A in children.

Outcome or subgroup title	No. of studies	No. of participants	Statistical method	Effect size
1 Fever day 3	3		Risk Ratio (M‐H, Random, 95% CI)	Subtotals only
1.1 AMT	2	104	Risk Ratio (M‐H, Random, 95% CI)	0.37 [0.08, 1.75]
1.2 RMT	1	69	Risk Ratio (M‐H, Random, 95% CI)	0.36 [0.14, 0.91]
2 Malaise day 6	1		Risk Ratio (M‐H, Random, 95% CI)	Subtotals only
2.1 RMT	1	69	Risk Ratio (M‐H, Random, 95% CI)	1.04 [0.63, 1.70]
3 Cough day 7	1	69	Risk Ratio (M‐H, Random, 95% CI)	0.83 [0.63, 1.10]
3.1 RMT	1	69	Risk Ratio (M‐H, Random, 95% CI)	0.83 [0.63, 1.10]
4 Conjunctivitis day 5	1		Risk Ratio (M‐H, Random, 95% CI)	Subtotals only
4.1 RMT	1	69	Risk Ratio (M‐H, Random, 95% CI)	0.17 [0.01, 3.49]
5 Eye symptoms day 5 (pain on movement and visual distortion)	1		Risk Ratio (M‐H, Random, 95% CI)	Subtotals only
5.1 RMT	1	69	Risk Ratio (M‐H, Random, 95% CI)	0.58 [0.10, 3.24]