Comparison 6. Adverse effects of amantadine and rimantadine compared to placebo or acetaminophen in children.

Outcome or subgroup title	No. of studies	No. of participants	Statistical method	Effect size
1 Diarrhoea	3	655	Risk Ratio (M‐H, Random, 95% CI)	0.79 [0.42, 1.47]
1.1 AMT	2	599	Risk Ratio (M‐H, Random, 95% CI)	0.81 [0.43, 1.53]
1.2 RMT	1	56	Risk Ratio (M‐H, Random, 95% CI)	0.36 [0.02, 8.41]
2 Exanthema	2	599	Risk Ratio (M‐H, Random, 95% CI)	0.69 [0.21, 2.34]
2.1 AMT	2	599	Risk Ratio (M‐H, Random, 95% CI)	0.69 [0.21, 2.34]
3 Muscular, limb pain	2	599	Risk Ratio (M‐H, Random, 95% CI)	0.85 [0.46, 1.59]
3.1 AMT	2	599	Risk Ratio (M‐H, Random, 95% CI)	0.85 [0.46, 1.59]
4 Headache	2	599	Risk Ratio (M‐H, Random, 95% CI)	0.73 [0.52, 1.03]
4.1 AMT	2	599	Risk Ratio (M‐H, Random, 95% CI)	0.73 [0.52, 1.03]
5 Stimulation/insomnia	2	599	Risk Ratio (M‐H, Random, 95% CI)	0.46 [0.12, 1.74]
5.1 AMT	2	599	Risk Ratio (M‐H, Random, 95% CI)	0.46 [0.12, 1.74]
6 Dizziness	3	655	Risk Ratio (M‐H, Random, 95% CI)	4.69 [0.53, 41.75]
6.1 AMT	2	599	Risk Ratio (M‐H, Random, 95% CI)	6.63 [0.32, 137.33]
6.2 RMT	1	56	Risk Ratio (M‐H, Random, 95% CI)	3.21 [0.14, 75.68]
7 Dyspnoea	1	159	Risk Ratio (M‐H, Random, 95% CI)	0.37 [0.02, 9.02]
7.1 AMT	1	159	Risk Ratio (M‐H, Random, 95% CI)	0.37 [0.02, 9.02]
8 Central nervous system symptoms	1	76	Risk Ratio (M‐H, Random, 95% CI)	0.23 [0.01, 4.70]
8.1 RMT	1	76	Risk Ratio (M‐H, Random, 95% CI)	0.23 [0.01, 4.70]
9 Change in behaviour	1	76	Risk Ratio (M‐H, Random, 95% CI)	0.23 [0.01, 4.70]
9.1 RMT	1	76	Risk Ratio (M‐H, Random, 95% CI)	0.23 [0.01, 4.70]
10 Gastrointestinal symptoms	1	76	Risk Ratio (M‐H, Random, 95% CI)	1.17 [0.08, 18.05]
10.1 RMT	1	76	Risk Ratio (M‐H, Random, 95% CI)	1.17 [0.08, 18.05]
11 Hyperreactivity	1	56	Risk Ratio (M‐H, Random, 95% CI)	0.36 [0.02, 8.41]
11.1 RMT	1	56	Risk Ratio (M‐H, Random, 95% CI)	0.36 [0.02, 8.41]
12 Tinnitus	1	56	Risk Ratio (M‐H, Random, 95% CI)	3.21 [0.14, 75.68]
12.1 RMT	1	56	Risk Ratio (M‐H, Random, 95% CI)	3.21 [0.14, 75.68]
13 Cerebellar ataxia	1	69	Risk Ratio (M‐H, Random, 95% CI)	2.61 [0.11, 61.80]
13.1 RMT	1	69	Risk Ratio (M‐H, Random, 95% CI)	2.61 [0.11, 61.80]
14 Malaise	2	599	Risk Ratio (M‐H, Random, 95% CI)	0.89 [0.41, 1.96]
14.1 AMT	2	599	Risk Ratio (M‐H, Random, 95% CI)	0.89 [0.41, 1.96]
15 Nausea/vomiting	4	724	Risk Ratio (M‐H, Random, 95% CI)	0.61 [0.24, 1.58]
15.1 AMT	2	599	Risk Ratio (M‐H, Random, 95% CI)	0.54 [0.15, 2.00]
15.2 RMT	2	125	Risk Ratio (M‐H, Random, 95% CI)	0.96 [0.10, 9.01]
16 Arrhythmia	2	599	Risk Ratio (M‐H, Random, 95% CI)	0.0 [0.0, 0.0]
16.1 AMT	2	599	Risk Ratio (M‐H, Random, 95% CI)	0.0 [0.0, 0.0]