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. 2014 Nov 21;2014(11):CD002745. doi: 10.1002/14651858.CD002745.pub4

Comparison 7. Adverse effects of rimantadine compared to placebo in the elderly.

Outcome or subgroup title No. of studies No. of participants Statistical method Effect size
1 Stimulation/insomnia 2 233 Risk Ratio (M‐H, Random, 95% CI) 1.61 [0.43, 6.02]
1.1 RMT 2 233 Risk Ratio (M‐H, Random, 95% CI) 1.61 [0.43, 6.02]
2 Confusion 2 233 Risk Ratio (M‐H, Random, 95% CI) 0.79 [0.40, 1.56]
2.1 RMT 2 233 Risk Ratio (M‐H, Random, 95% CI) 0.79 [0.40, 1.56]
3 Fatigue 2 233 Risk Ratio (M‐H, Random, 95% CI) 0.81 [0.41, 1.60]
3.1 RMT 2 233 Risk Ratio (M‐H, Random, 95% CI) 0.81 [0.41, 1.60]
4 Vomiting 2 233 Risk Ratio (M‐H, Random, 95% CI) 0.99 [0.38, 2.60]
4.1 RMT 2 233 Risk Ratio (M‐H, Random, 95% CI) 0.99 [0.38, 2.60]
5 Headache 1 198 Risk Ratio (M‐H, Random, 95% CI) 0.83 [0.21, 3.38]
5.1 RMT 1 198 Risk Ratio (M‐H, Random, 95% CI) 0.83 [0.21, 3.38]
6 Impaired concentration 1 198 Risk Ratio (M‐H, Random, 95% CI) 0.5 [0.10, 2.41]
6.1 RMT 1 198 Risk Ratio (M‐H, Random, 95% CI) 0.5 [0.10, 2.41]
7 Rash or allergic reaction 1 198 Risk Ratio (M‐H, Random, 95% CI) 3.53 [0.18, 67.28]
7.1 RMT 1 198 Risk Ratio (M‐H, Random, 95% CI) 3.53 [0.18, 67.28]
8 Seizures or clonic twitching 1 198 Risk Ratio (M‐H, Random, 95% CI) 2.0 [0.23, 17.54]
8.1 RMT 1 198 Risk Ratio (M‐H, Random, 95% CI) 2.0 [0.23, 17.54]
9 Dry mouth 1 198 Risk Ratio (M‐H, Random, 95% CI) 0.7 [0.23, 2.12]
9.1 RMT 1 198 Risk Ratio (M‐H, Random, 95% CI) 0.7 [0.23, 2.12]
10 Dizziness 1 35 Risk Ratio (M‐H, Random, 95% CI) 0.94 [0.15, 5.97]
10.1 RMT 1 35 Risk Ratio (M‐H, Random, 95% CI) 0.94 [0.15, 5.97]
11 Anxiety 1 35 Risk Ratio (M‐H, Random, 95% CI) 2.83 [0.92, 8.74]
11.1 RMT 1 35 Risk Ratio (M‐H, Random, 95% CI) 2.83 [0.92, 8.74]
12 Nausea 2 233 Risk Ratio (M‐H, Random, 95% CI) 1.99 [0.45, 8.75]
12.1 RMT 2 233 Risk Ratio (M‐H, Random, 95% CI) 1.99 [0.45, 8.75]
13 Depression 2 233 Risk Ratio (M‐H, Random, 95% CI) 1.63 [0.53, 4.98]
13.1 RMT 2 233 Risk Ratio (M‐H, Random, 95% CI) 1.63 [0.53, 4.98]
14 Loss of appetite 2 233 Risk Ratio (M‐H, Random, 95% CI) 1.11 [0.56, 2.17]
14.1 RMT 2 233 Risk Ratio (M‐H, Random, 95% CI) 1.11 [0.56, 2.17]