| Methods |
Randomised double‐blind placebo‐controlled trial |
| Participants |
Depressed inpatients aged 6‐12 years
1 female, 5 male
3 active treatment, 3 placebo
1 withdrawal |
| Interventions |
Imipramine 5 mg/kg/day |
| Outcomes |
Children's Depression Inventory
Follow‐up interval 6 weeks |
| Notes |
Study quality score = 22 |
| Risk of bias |
| Bias |
Authors' judgement |
Support for judgement |
| Random sequence generation (selection bias) |
Unclear risk |
Study described as random but no further description was provided |
| Allocation concealment (selection bias) |
Unclear risk |
No description was provided |
| Blinding (performance bias and detection bias)
of participants |
Unclear risk |
Described as blind but no description was provided |
| Blinding (performance bias and detection bias)
of personnel |
Low risk |
Visually identical tablets and uniform frequency was used |
| Blinding (performance bias and detection bias)
of outcome assessors |
Unclear risk |
Described as blind but no description was provided |
| Incomplete outcome data (attrition bias)
All outcomes |
Unclear risk |
Number and reason for withdrawal was provided but analysis was not modified |
| Selective reporting (reporting bias) |
Unclear risk |
‐ |
| Other bias |
Unclear risk |
Previous treatment and comorbidity was not stated |
