Bernstein 2000.

Methods	Randomised double‐blind control trial of imipramine versus placebo each in combination with cognitive behavioural therapy
Participants	Outpatients aged 12‐18 years referred with school refusal 38 females, 25 males 31 active treatment, 32 placebo 16 withdrawals
Interventions	Imipramine up to 3 mg/kg in 2 divided dose
Outcomes	Anxiety Rating for Children‐Revised Children's Depression Rating Scale‐Revised Revised Children's Manifest Anxiety Scale Beck Depression Inventory School attendance Side Effects Rating Clinical Global Impressions Follow‐up interval 2 weeks Family Adaptability and Cohesion Evaluation Scale II
Notes	Study quality score = 28
Risk of bias
Bias	Authors' judgement	Support for judgement
Random sequence generation (selection bias)	Unclear risk	Study was described as random but no further description was provided
Allocation concealment (selection bias)	Unclear risk	No description was provided
Blinding (performance bias and detection bias) of participants	Unclear risk	No description was provided
Blinding (performance bias and detection bias) of personnel	Unclear risk	No description was provided
Blinding (performance bias and detection bias) of outcome assessors	Low risk	Assessors were an independent child psychiatrist who was not involved with the earlier stages of the study
Incomplete outcome data (attrition bias) All outcomes	Unclear risk	Number and reason for withdrawal was provided but analysis was not modified
Selective reporting (reporting bias)	Unclear risk	‐
Other bias	Unclear risk	Previous treatment was not stated