Table 2.

Hazard ratios for renal crisis from a multivariable Cox proportional hazard model based on the medication dataset. All variables with p < 0.2 in the univariable analyses were included

	No. of renal crises/patients	Hazard ratio (95% CI)	P value
Age (per decade)	78/6083	1.06 (0.87–1.28)	0.56
Sex (male)		1.30 (0.74–2.28)	0.36
Diffuse skin involvement		1.79 (1.06–3.02)	0.030
Time since onset of scleroderma (per decade)		0.77 (0.55–1.08)	0.13
Arterial hypertension		2.22 (1.34–3.66)	0.002
Tendon friction rub		1.70 (0.83–3.48)	0.15
ACE inhibitors		2.07 (1.28–3.36)	0.003
SCL70-positive		0.98 (0.58–1.66)	0.94
ACA-positive		0.82 (0.45–1.49)	0.52
Glucocorticoids > 10 mg		1.49 (0.53–4.17)	0.45
PDE5 inhibitors		1.32 (0.60–2.87)	0.49