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The expression of β-catenin protein varies in primary ccRCCs and metastatic ccRCCs. a: primary ccRCCs, b: metastatic ccRCCs, × 400. a weak positivity for β-catenin protein. b positivity for β-catenin protein. c Schematic of the pathway of RCC invasion and metastasis. RSK4 may be mediated through the regulation of CD44 and MMP-9 expression, while RSK4-mediated CD44 and MMP-9 may be mediated through the GSK 3β, β-catenin pathway or rps6 phosphorylation
