Table 1.

Demographics and clinical features of 13 patients with perianal Paget’s disease

Case	Age (years)	Sex	Clinical presentation	Other malignancies	Underlying malignancy (Immunoprofile)	Metastasis	Outcome	Follow up (month)	Treatment other than surgery
1	75	M	Perianal erosive plaque	Chronic myeloid leukemia	None	N/A	Dieda	60	Radiation
2	79	F	Discomfort	Follicular lymphoma; breast carcinoma; urothelial carcinoma in-situ	None	N/A	Alive	83	None
3	61	M	Itching and irritation of the perianal area; erythema with whitish plaques	None	None	N/A	Alive	31	None
4	86	M	Perianal lesion	Basal cell carcinoma	None	N/A	Alive	4
5	81	M	Discomfort	None	Mixed moderately differentiated adenocarcinoma with mucinous features and neuroendocrine (large cell) carcinoma (CK7+/CK20+/CDX2+)	Lymph nodes and liver	Dieda	79	None
6	53	F	Acute anal fissure, anal lesion	Basal cell carcinoma; breast carcinoma	Adenocarcinoma, well differentiated (CK7−/CK20+/CDX2+)	None	Alive	61	None
7	86	M	Discomfort	None	Adenocarcinoma, poorly differentiated (CK7+/CK20-)	None	Alive	52	None
8	69	F	None (detected during routine colon cancer screening biopsy)	None	Adenocarcinoma, moderately differentiated (CK7+/CK20+/CDX2+)	None	Alive	16	None
9	83	M	Perianal rash and lesion with ulceration	Basal cell carcinoma	Adenocarcinoma, moderately differentiated (CK7−/CK20+/CDX2+)	None	Alive	7	Chemoradiation
10	69	F	Anal/perianal rash and lesion	None	Adenocarcinoma with neuroendocrine and signet ring features (CK7+/CK20+/CDX2+)	None	Alive	21	None
11	50	M	Anal fistula	None	Adenocarcinoma with mucinous features	Lymph nodes	Alive	227	Chemotherapy
12	70	M	Perianal lesion	None	Mucinous adenocarcinoma (CK7+/CK20+/CDX2+)	Lymph nodes, liver and bone	Alive	47	Chemoradiation
13	77	M	None	None	Tubular adenoma with high-grade dysplasia (CK7−/CK20+/CDX2+)	None	Alive	6	None

^aCase #1 died of chronic myeloid leukemia. Case #5 died of disease progression. N/A, not applicable